DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5µM respectively) that blocks DNA binding (Ki = 5µM for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.
Chemical Name: 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone
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