Tocris™ L189

DNA ligase I, III and IV inhibitor

Manufacturer: Tocris™ 3561/10

 View more versions of this product

Catalog No. 35-611-0R

  Check Availability
Add to Cart

Disclaimers:

For Research Use Only


    Specifications

    Product Type L189
    Inhibitors L189
    Molecular Weight 246.29
    Quantity 10mg

    DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5µM respectively) that blocks DNA binding (Ki = 5µM for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.

    • Chemical Name: 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone
    • Formula: C11H10N4OS
    • CAS Number: 64232-83-3
    • Solubility: Soluble to 100mM in DMSO

  • Description & Specifications

Related Products


Product Content Feedback

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit