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L1CAM Mouse anti-Human, Clone: SPM275, Novus Biologicals™
Mouse Monoclonal Antibody
Supplier: Novus Biologicals NBP2330160.1MG
SDSDocumentsProduct Certifications Promotions
DescriptionL1CAM Monoclonal specifically detects L1CAM in Human samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Frozen.
|PBS with 0.05% BSA. with 0.05% Sodium Azide|
|antigen identified by monoclonal R1, CAML1N-CAML1, CD171, CD171 antigen, HSAS, HSAS1, L1 cell adhesion molecule, MASA, MIC5, N-CAM-L1, NCAM-L1, neural cell adhesion molecule L1, S10, SPG1|
|Protein A purified|
|Recognizes a cell surface protein of 220-240kDa, identified as L1 cell adhesion molecule. The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); 2) MASA (mental retardation, aphasia, shuffling gait, and adducted thumbs); and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, and neural migration as well as in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm. This MAb is useful in the identification of primitive neuroectodermal tumors. It binds to tumors of neuroectodermal and glial origin e.g. neuroblastoma and Schwannomas. It does not bind to pediatric or adult brain.|
|Store at 4C.|
|Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Frozen)|
|Western Blot 0.5-1.0ug/ml, Flow Cytometry 0.5-1ug/million cells, Immunocytochemistry/Immunofluorescence 1-2ug/ml, Immunoprecipitation 0.5-1ug/500ug protein lysate, Immunohistochemistry-Frozen 1-2ug/ml|
|Homogenous suspension of 16 week human fetal brain|
|Cellular Markers, Glia Markers, Neuroscience, Phospho Specific|
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