L1CAM Mouse anti-Human, Clone: SPM275, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP2330160.02MG

Catalog No. NBP233016F

Description

L1CAM Monoclonal specifically detects L1CAM in Human samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Frozen.

Specifications

• Antigen: L1CAM
• Classification: Monoclonal
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA. with 0.05% Sodium Azide
• Gene Alias: antigen identified by monoclonal R1, CAML1N-CAML1, CD171, CD171 antigen, HSAS, HSAS1, L1 cell adhesion molecule, MASA, MIC5, N-CAM-L1, NCAM-L1, neural cell adhesion molecule L1, S10, SPG1
• Host Species: Mouse
• Purification Method: Protein A purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Recognizes a cell surface protein of 220-240kDa, identified as L1 cell adhesion molecule. The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); 2) MASA (mental retardation, aphasia, shuffling gait, and adducted thumbs); and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, and neural migration as well as in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm. This MAb is useful in the identification of primitive neuroectodermal tumors. It binds to tumors of neuroectodermal and glial origin e.g. neuroblastoma and Schwannomas. It does not bind to pediatric or adult brain.
• Content And Storage: Store at 4C.
• Isotype: IgG1 κ

• Applications: Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Frozen)
• Clone: SPM275
• Dilution: Western Blot 0.5-1.0ug/ml, Flow Cytometry 0.5-1ug/million cells, Immunocytochemistry/Immunofluorescence 1-2ug/ml, Immunoprecipitation 0.5-1ug/500ug protein lysate, Immunohistochemistry-Frozen 1-2ug/ml
• Gene Accession No.: P32004
• Gene Symbols: L1CAM
• Immunogen: Homogenous suspension of 16 week human fetal brain
• Quantity: 0.02 mg
• Research Discipline: Cellular Markers, Glia Markers, Neuroscience, Phospho Specific
• Gene ID (Entrez): 3897
• Target Species: Human
• Form: Purified