Epredia™ Lab Vision™ Actin, Smooth Muscle, Ab-1 Mouse Monoclonal Antibody, 40μg/mL, BSA and azide

Ensure accurate, reproducible results in western blotting and immunoprecipitation experiments with Epredia™ Caspase 8 (FLICE) Ab-3, Mouse Monoclonal Antibody.

Supplier:  Epredia™ MS1143P

Catalog No. MS1143P

Description

Caspase 8 binds to the death effector domain (DED) of FADD through an analogous DED domain present in tandem in the proform of the caspase 8 protein. Recruitment of caspase 8 to the Fas receptor results in oligomerization of the caspase 8 protein, which in turn drives its autoactivation through “self-cleavage”. Activated caspase 8 then activates other downstream caspases including caspase 9, thereby commiting the cell to undergo apoptosis.

Host Species: Mouse

Clone: 8CSP03; same as 4.1.20

Isotype: IgG1

Species Reactivity: Human. Others not tested.

Epitope: Not determined

Immunogen: Recombinant full-length human Caspase 8 protein

Molecular Weight: 55 kDa

Positive Control: Jurkat cells

Cellular Localization: Cytoplasmic

Recommended for:

• Western Blotting
• Immunoprecipitation (Denatured verified)

Note:

USA: RUO; Int'l: RUO

Specifications

• Antigen: Caspase 8 (FLICE) Ab-3
• Classification: Monoclonal
• Concentration: 200μg/mL
• Host Species: Mouse
• Quantity: 1 mL
• Research Discipline: Apoptosis
• Target Species: Human
• Isotype: IgG1

• Applications: Immunoprecipitation, Western Blot
• Clone: 8CSP03; same as 4.1.20
• Conjugate: Unconjugated
• Immunogen: Recombinant full length human Caspase 8 protein
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Form: Concentrated