Epredia™ Lab Vision™ ALK (Anaplastic Lymphoma Kinase)/p80 Rabbit Monoclonal Antibody

Obtain accurate, reproducible results in immunohistochemistry experiments with Epredia™ ALK (Anaplastic Lymphoma Kinase)/p80, Rabbit Monoclonal Antibody.

Supplier:  Epredia™ RM9108R1

Catalog No. RM9108R1

Description

Recognizes a human p80 protein, identified as a hybrid of the anaplastic lymphoma kinase (ALK) gene and the nucleophosmin (NPM) gene resulting from the t(2;5)(p23;q35) translocation found in 30-50% of CD30+ large cell lymphomas (1). This rabbit monoclonal antibody can be used to detect p80 in these lymphomas and may also be used to detect a recently described subtype of large B cell lymphoma, which expresses the full-length ALK protein (2).

Host Species: Rabbit

Clone: SP8

Isotype: IgG

Species Reactivity: Human. Others not tested.

Epitope: Not determined

Immunogen: Recombinant protein corresponding to a region which spans the tyrosine kinase catalytic domain and part of the C-terminus of the NPM-ALK transcript

Positive Control: Anaplastic lymphoma

Cellular Localization: Cytoplasmic + nuclear Clone SP8 is excellent for staining of formalin/paraffin with no special pretreatment

Recommended for:

• Immunohistochemistry (Formalin/paraffin)

Specifications

• Antigen: ALK (Anaplastic Lymphoma Kinase)/p80
• Classification: Monoclonal
• Conjugate: Unconjugated
• Immunogen: Recombinant protein corresponding to a region, which spans the tyrosine kinase catalytic domain and part of the C-terminus of the NPM-ALK transcript
• Regulatory Status: IVD
• Primary or Secondary: Primary
• Form: Prediluted

• Applications: Immunohistochemistry (Paraffin)
• Clone: SP8
• Host Species: Rabbit
• Quantity: 1 mL
• Research Discipline: Cancer and Tumor Biology
• Target Species: Human
• Isotype: IgG