Epredia™ Lab Vision™ Calponin-1 Rabbit Monoclonal Antibody
Obtain accurate, reproducible results in immunohistochemistry procedures with Epredia™ Calponin-1, Rabbit Monoclonal Antibody.
Manufacturer: Epredia™ RM2102R1
DescriptionCalponin, a thin filament associated protein, is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. Calponin is expressed in smooth muscle and tissues containing significant amounts of smooth muscle. Two isoforms of calponin exist whose molecular weights are 34 kDa and 29 kDa. Expression of the 29 kDa form is primarily restricted to muscle of the urogenital tract. The expression of calponin has also been demonstrated in myoepithelial cells from benign and malignant breast lesions. It stains smooth muscle, myoepithelial cells, myofibroblasts, keratinocytes and nerve fibers. It identifies myoepithelial cells in breast lesions, and helps differentiate breast collagenous spherulosis (positive) from adenoid cystic carcinoma. Adenoid cystic carcinoma in salivary gland tumors is calponin positive.
Host Species: Rabbit
Species Reactivity: Human. Others not known.
Immunogen: A synthetic peptide derived from near the C-terminus of human Calponin-1
Molecular Weight: 29/34 kDa
Positive Control: Breast CA
Cellular Localization: Cytoplasm Myoepithelial cells
- Immunohistochemistry (Formalin/paraffin)
|A synthetic peptide derived from near the C-terminus of human Calponin-1|
|Cancer and Tumor Biology|
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