Epredia™ Lab Vision™ CD115/c-fms/CSF-1R/M-CSFR Ab-1 Rat Monoclonal Antibody with BSA and azide

Ensure accurate, reproducible results in immunohistochemistry and immunofluorescence experiments.

Supplier:  Epredia™ RT601P1

Catalog No. RT601P1

Description

CD115, also known as c-fms, macrophage Colony Stimulating Factor Receptor (M-CSFR), or CSF-1R, exists in immature (gp130c-fms) and mature (gp150^c-fms) forms. CSF-1R exhibits an intrinsic tyrosine-specific protein kinase activity. It is expressed on the cells of the mononuclear phagocyte lineage. CSF-1R is an integral transmembrane glycoprotein consisting of a 512 amino acid extracellular domain that includes the CSF-1 binding site, a single 25 amino acid membrane-spanning segment, and a 435 amino acid cytoplasmic portion that includes the tyrosine kinase domain.

Host Species: Rat

Clone: 2-4A5-4

Isotype: IgG1/κ

Species Reactivity: Human. Does not react with mouse and cat. Others not known.

Epitope: aa 349-512

Immunogen: v-ras-transformed rat NRK cells expressing transduced human CSF-1R

Molecular Weight: 130 and 150 kDa

Positive Control: Tonsil

Cellular Localization: Membrane

Recommended for:

• Immunohistochemistry (Acetone-fixed frozen)
• Immunofluorescence
• Blocks Ligand Binding
• Blocks Ligand-dependent Proliferation
• Inhibits CSF-1-independent Growth of Cells Expressing Mutant CSF-1R

Note:

USA: RUO; Int'l: RUO

Specifications

• Antigen: CD115
• Classification: Monoclonal
• Concentration: 200µg/mL
• Host Species: Rat
• Quantity: 500 μL
• Primary or Secondary: Primary
• Form: Concentrated

• Applications: Immunohistochemistry (Frozen)
• Clone: 2-4A5-4
• Conjugate: Unconjugated
• Immunogen: v-ras-transformed rat NRK cells expressing transduced human CSF-1R
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG2a κ