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Epredia™ Lab Vision™ CD115/c-fms/CSF-1R/M-CSFR Ab-1 Rat Monoclonal Antibody with BSA and azide
Ensure accurate, reproducible results in immunohistochemistry and immunofluorescence experiments.
Supplier: Epredia™ RT601P
Description
CD115, also known as c-fms, macrophage Colony Stimulating Factor Receptor (M-CSFR), or CSF-1R, exists in immature (gp130c-fms) and mature (gp150c-fms) forms. CSF-1R exhibits an intrinsic tyrosine-specific protein kinase activity. It is expressed on the cells of the mononuclear phagocyte lineage. CSF-1R is an integral transmembrane glycoprotein consisting of a 512 amino acid extracellular domain that includes the CSF-1 binding site, a single 25 amino acid membrane-spanning segment, and a 435 amino acid cytoplasmic portion that includes the tyrosine kinase domain.Host Species: Rat
Clone: 2-4A5-4
Isotype: IgG1/κ
Species Reactivity: Human. Does not react with mouse and cat. Others not known.
Epitope: aa 349-512
Immunogen: v-ras-transformed rat NRK cells expressing transduced human CSF-1R
Molecular Weight: 130 and 150 kDa
Positive Control: Tonsil
Cellular Localization: Membrane
Recommended for:
- Immunohistochemistry (Acetone-fixed frozen)
- Immunofluorescence
- Blocks Ligand Binding
- Blocks Ligand-dependent Proliferation
- Inhibits CSF-1-independent Growth of Cells Expressing Mutant CSF-1R
Note:
USA: RUO; Int'l: RUO
Specifications
CD115 | |
Monoclonal | |
200µg/mL | |
Rat | |
1 mL | |
Primary | |
Concentrated |
Immunohistochemistry (Frozen) | |
2-4A5-4 | |
Unconjugated | |
v-ras-transformed rat NRK cells expressing transduced human CSF-1R | |
RUO | |
Human | |
IgG2a κ |
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