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HER-2/c-erbB-2/neu Ab-2 Mouse Monoclonal Antibody, Epredia™
Provide accurate, reproducible results with the Epredia™ HER-2/c-erbB-2/neu Ab-2, Mouse Monoclonal Antibody.
Supplier: Epredia MS229P1ABX
Description
c-erbB-2, second member (c-erbB-2/HER-2/neu) of the c-erbB family is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25% of primary breast and ovarian tumors were found to overexpress the proteinHost Species: Mouse
Clone: 9G6.10
Isotype: IgG1
Species Reactivity: Human. Does not react with mouse and rat. Others not tested.
Epitope: Extracellular domain
Immunogen: RAC311 cells transfected with SV40-neu construct, expressing human neu protein
Molecular Weight: 185kDa
Positive Control: SKBR-3 cells, or Breast CA
Cellular Localization: Membrane
Recommended for:
- Immunohistochemistry (Frozen only) Immunofluorescence
- Immunoprecipitation
- Flow Cytometry
- Inhibits Colony Formation
- Partially Inhibits Tyrosine Kinase Activity
Note:
USA: RUO; Int'l: RUO
Specifications
HER-2/c-erbB-2/neu Ab-2 | |
Monoclonal | |
1mg/mL | |
Mouse | |
100 μL | |
Oncogenesis | |
Human | |
IgG1 |
Flow Cytometry, Immunofluorescence, Immunohistochemistry (Frozen), Immunoprecipitation | |
9G6.10 | |
Unconjugated | |
RAC311 cells transfected with SV40-neu construct, expressing human neu protein | |
RUO | |
Primary | |
Concentrated |
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