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HER-2/c-erbB-2/neu Ab-2 Mouse Monoclonal Antibody, Epredia™

Provide accurate, reproducible results with the Epredia™ HER-2/c-erbB-2/neu Ab-2, Mouse Monoclonal Antibody.

Manufacturer:  Epredia MS229P

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Catalog No. MS229P

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

c-erbB-2, second member (c-erbB-2/HER-2/neu) of the c-erbB family is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25% of primary breast and ovarian tumors were found to overexpress the protein

Host Species: Mouse

Clone: 9G6.10

Isotype: IgG1

Species Reactivity: Human. Does not react with mouse and rat. Others not tested.

Epitope: Extracellular domain

Immunogen: RAC311 cells transfected with SV40-neu construct, expressing human neu protein

Molecular Weight: 185kDa

Positive Control: SKBR-3 cells, or Breast CA

Cellular Localization: Membrane

Recommended for:

  • Immunohistochemistry (Frozen only) Immunofluorescence
  • Immunoprecipitation
  • Flow Cytometry
  • Inhibits Colony Formation
  • Partially Inhibits Tyrosine Kinase Activity

Note:

USA: RUO; Int'l: RUO

Specifications

Specifications

HER-2/c-erbB-2/neu Ab-2
Monoclonal
200μg/mL
Mouse
1 mL
Oncogenesis
Human
IgG1
Flow Cytometry, Immunofluorescence, Immunohistochemistry (Frozen), Immunoprecipitation
9G6.10
Unconjugated
RAC311 cells transfected with SV40-neu construct, expressing human neu protein
RUO
Primary
Concentrated
SDS
Documents
Product Certifications
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