IGF-1R (α-subunit) Ab-4 Mouse Monoclonal Antibody, Epredia™
Epredia™ IGF-1R (α-Subunit) Ab-4, Mouse Monoclonal Antibody provides accurate, reproducible results.
Manufacturer: Epredia MS644P1ABX
DescriptionIGF-1R (Insulin-like Growth Factor-1 Receptor) consists of α- and Β-subunits, which are disulfide-linked in a Β-α-α-Β configuration in the mature receptor. The α-subunit is completely extracellular, while the Β-subunit spans the membrane and the intracellular portion has intrinsic tyrosine kinase activity.
Host Species: Mouse
Species Reactivity: Human. Weakly reacts with Rabbit and Pig (Ab-2 is better). Does not react with rat.
Epitope: aa 184-283
Immunogen: IGF-1R/3T3 mouse fibroblasts transfected with human type I IGF-receptor cDNA
Molecular Weight: 125kDa
Positive Control: Placenta or Breast CA
Cellular Localization: Membrane Ab-4 is excellent for immunoprecipitation of alpha-subunit of IGF-1R.
- Western Blotting (Not suitable)
- Acts as a Weak IGF-like Agonist in Bioassays (Thymidine incorporation into DNA)
- Substantially (>80%) Inhibits IGF-1 Binding
USA: RUO; Int'l: RUO
|IGF-1R (alpha-Subunit) Ab-4|
|IGF-1R/3T3 mouse fibroblasts transfected with human type I IGF-receptor cDNA|
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