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Epredia™ Lab Vision™ p57Kip2 Ab-7 Rabbit Polyclonal Antibody with BSA and azide
Deliver accurate, reproducible results with the Epredia™ p57Kip2 Ab-7, Rabbit Polyclonal Antibody.
Specifications
Antigen | p57superscriptKip2superscript Ab-7 |
---|---|
Applications | Immunohistochemistry (Paraffin) |
Classification | Polyclonal |
Conjugate | Unconjugated |
Host Species | Rabbit |
Catalog Number | Mfr. No. | Form | Quantity | Price | Quantity & Availability | ||||
---|---|---|---|---|---|---|---|---|---|
Catalog Number | Mfr. No. | Form | Quantity | Price | Quantity & Availability | ||||
RB1637R1
|
Epredia™
RB1637R1 |
Prediluted | 1 mL | Item Discontinued This item has been discontinued by the supplier. Please Sign In to view product availability in your area. | N/A | ||||
Description
p57Kip2 (or CDKN1C) is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57Kip2 is located on chromosome 11p15.5, a region implicated in both sporadic cancers, Wilm's tumor, and Beckwith-Wiedemann syndrome (BWS), a cancer syndrome, making it a tumor suppressor candidate. BWS is characterized by numerous growth abnormalities and an increased risk of childhood tumors. Several types of childhood tumors including Wilms' tumor, adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. This region also contains two other imprinted genes, insulin-like growth factor II (IGF-II) and H19, both of which seem to be implicated in adrenal neoplasms.Host Species: Rabbit
Isotype: IgG
Species Reactivity: Human, Cow and Mouse. Others not known.
Epitope: Near C-terminus
Immunogen: A synthetic peptide from human p57Kip2 protein
Molecular Weight: 57kDa
Positive Control: Colon CA or placenta
Cellular Localization: Nuclear
Recommended for:
- Immunohistochemistry (Formalin/paraffin)
- Western Blotting (Not suitable)
Note:
USA: RUO; Int'l: RUO
Specifications
p57superscriptKip2superscript Ab-7 | |
Polyclonal | |
Rabbit | |
Cancer and Tumor Biology | |
IgG |
Immunohistochemistry (Paraffin) | |
Unconjugated | |
RUO | |
A synthetic peptide from human p57superscriptKip2superscript protein | |
Primary |
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