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Epredia™ Lab Vision™ SREBP-1 (Sterol Regulatory Element Binding Protein-1) Ab-1 Mouse Monoclonal Antibody, 200µg/mL, BSA and azide

Epredia™ SREBP-1 (Sterol Regulatory Element Binding Protein-1) Ab-1, Mouse Monoclonal Antibody provides accurate, reproducible results.

Manufacturer:  Epredia™ MS1207PABX

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Catalog No. MS1207PABX


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Description

Description

SREBP-1 and -2 are transcription factors which participate in the control of cholesterol homeostasis. SREBPs proteins, which are attached to the endoplasmic reticulum and nuclear envelope, are proteolytically cleaved and thus activated in response to conditions of low cellular sterol. Upon activation of SREBP-1 or -2, an ∽480-500 amino acid, N-terminal cleavage fragment of these proteins enters the nucleus and activates transcription of enzymes and other proteins required for cholesterol synthesis. SCA (SREBP-cleavage activity) and caspase-3 proteases cleave SREBPs. SREBP proteins containing point mutations at caspase-3 cleavage sites (Asp460 in SREBP-1 and Asp468 in SREBP-2) do not become cleaved following induction of apoptosis, suggesting that SREBPs may play some role in apoptotic processes.

Host Species: Mouse

Clone: 2A4

Isotype: IgG1/κ

Species Reactivity: Human and Hamster. Others not known.

Epitope: aa 301-407

Immunogen: Recombinant protein encoding N-terminal amino acids 301-407 (the bHLH/leucine zipper domain) of human SREBP-1

Molecular Weight: 125kDa (precursor) and 60-70kDa (cleaved)

Positive Control: HeLa and IMR5 cells

Cellular Localization: Cytoplasmic and nuclear

Recommended for:

  • Western Blotting
  • Immunoprecipitation (Not verified)

Note:

USA: RUO; Int'l: RUO

Specifications

Specifications

SREBP-1 (Sterol Regulatory Element Binding Protein-1) Ab-1
Monoclonal
1mg/mL
Mouse
200 μL
Transcription Regulation
Hamster, Human
IgG2a κ
Immunoprecipitation, Western Blot
2A4
Unconjugated
Recombinant protein encoding N-terminal amino acids 301-407 (the bHLH/leucine zipper domain) of human SREBP-1
RUO
Primary
Concentrated
SDS
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