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LAIR1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA587648
SDSDocumentsProduct Certifications Promotions
Positive Samples: B-cell, Jurkat, HL-60, Raji, Mouse brain, Mouse liver, Mouse lung, Rat liver; Cellular Location: Cell membrane, Single-pass type I membrane proteinLAIR1 (CD305) functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
|Recombit protein of human LAIR1|
|Human, Mouse, Rat|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|P0C1X9, Q6GTX8, Q8BG84|
|Antigen Affinity Chromatography|
|3903, 52855, 574531|
|-20° C, Avoid Freeze/Thaw Cycles|
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