Lamin A/C R453W Monoclonal Antibody (12A-2F5), Active Motif™

Mouse Monoclonal Antibody

Supplier:  Active Motif 39959

Catalog No. 50-199-3001

Description

Lamins are a class of intermediate filament proteins that form a matrix on the inner surface of the nuclear envelope. These proteins are found in many different cell types in three different forms (A, B, and C). Lamins A and C are alternatively spliced versions of the LMNA gene. The LMNA gene has been linked to many disorders of the muscular system, nervous system, and the fat distributions systems including: Emery-Dreifuss muscular dystrophy, Dunnigan-type familial partial lipodystrophy (FPLD), limb-girdle muscular dystrophy (LGMD1B), dilated cardiomyopathy (CMD1A), axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1), and mandibuloacral dysplasia (MAD).

Specifications

• Antigen: Lamin A/C R453W
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
• Gene Accession No.: P02545
• Gene Symbols: LMNA
• Immunogen: This Lamin A/C R453W antibody was raised against a peptide consisting of amino acids 449-457 of human Lamin A/C containing the R453W substitution.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
• Clone: 12A-2F5
• Conjugate: Unconjugated
• Gene: LMNA
• Gene Alias: 70 kDa lamin; CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; lamin; lamin A/C; lamin A/C-like 1; Lamin A+C mutant; Lamin AC; Lamin-A/C; LDP1; LFP; LGMD1B; LMN1; LMNA; LMNC; LMNL1; mutant 453W; Mutant lamin A/C; Prelamin-A/C; PRO1; progerin mutant; Renal carcinoma antigen NY-REN-32; RP11-54H19.1
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 4000
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid