Lamin A/C R453W Monoclonal Antibody (12A-2F5), Active Motif™
Mouse Monoclonal Antibody
Supplier: Active Motif 39960
DescriptionLamins are a class of intermediate filament proteins that form a matrix on the inner surface of the nuclear envelope. These proteins are found in many different cell types in three different forms (A, B, and C). Lamins A and C are alternatively spliced versions of the LMNA gene. The LMNA gene has been linked to many disorders of the muscular system, nervous system, and the fat distributions systems including: Emery-Dreifuss muscular dystrophy, Dunnigan-type familial partial lipodystrophy (FPLD), limb-girdle muscular dystrophy (LGMD1B), dilated cardiomyopathy (CMD1A), axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1), and mandibuloacral dysplasia (MAD).
|Lamin A/C R453W|
|70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8|
|This Lamin A/C R453W antibody was raised against a peptide consisting of amino acids 449-457 of human Lamin A/C containing the R453W substitution.|
|Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot|
|70 kDa lamin; CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; lamin; lamin A/C; lamin A/C-like 1; Lamin A+C mutant; Lamin AC; Lamin-A/C; LDP1; LFP; LGMD1B; LMN1; LMNA; LMNC; LMNL1; mutant 453W; Mutant lamin A/C; Prelamin-A/C; PRO1; progerin mutant; Renal carcinoma antigen NY-REN-32; RP11-54H19.1|
|-20°C, Avoid Freeze/Thaw Cycles|
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