Lamin A/C R482W Mouse anti-Human, Clone: 5H8-B4, Active Motif™
Mouse Monoclonal Antibody
Manufacturer: Active Motif 39964
DescriptionLamins are a class of intermediate filament proteins that form a matrix on the inner surface of the nuclear envelope. These proteins are found in many different cell types in three different forms (A, B, and C). Lamins A and C are alternatively spliced versions of the LMNA gene. The LMNA gene has been linked to many disorders of the muscular system, nervous system, and the fat distributions systems including: Emery-Dreifuss muscular dystrophy, Dunnigan-type familial partial lipodystrophy (FPLD), limb-girdle muscular dystrophy (LGMD1B), dilated cardiomyopathy (CMD1A), axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1), and mandibuloacral dysplasia (MAD).
|Lamin A/C R482W|
|Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot|
|70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8|
|-20°C, Avoid Freeze/Thaw Cycles|
|This Lamin A/C R482W antibody was raised against a recombinant protein corresponding to amino acids 430-545 of human Lamin A/C containing the R482W substitution.|
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