Laminin alpha-2 Mouse anti-Human, Mouse, Rat, Clone: CL3450, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA524656
Immunogen sequence: DKLKPIKELE DNLKKNISEI KELINQARKQ ANSIKVSVSS GGDCIRTYKP EIKKGSYNNI VVNVKTAVAD NLLFYLGSAK FIDFLAIEMR KGKVSFLWDV GSGVGRVEYP DLTIDDSYWY RIVASRTGRN GT Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 98%. Binds to an epitope located within the peptide sequence DKLKPIKELEDNLKK as determined by overlapping synthetic peptides.Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene.
|PBS with 40% glycerol and 0.02% sodium azide; pH 7.2|
|LAMM, laminin M, laminin alpha-2, merosin heavy chain,|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|16773, 309368, 3908|
|Immunohistochemistry, Western Blot|
|Recombit protein corresponding to Human Laminin alpha-2|
|Human, Mouse, Rat|
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