Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Laminin alpha-4 Mouse anti-Human, Mouse, Rat, Clone: CL3183, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524650

Catalog No. PIMA524650


Add to cart

Description

Description

Immunogen sequence: ENLLNQAREL QAKAESSSDE AVADTSRRVG GALARKSALK TRLSDAVKQL QAAERGDAQQ RLGQSRLITE EANRTTMEVQ QATAPMANNL TNWSQNLQHF DSSAYNTAVN SARDAVRNLT EVVPQLLDQL RTVEQKRPAS Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 85%. Binds to an epitope located within the peptide sequence MANNLTNWSQNLQHF as determined by overlapping synthetic peptides.

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of alternative polyA-signal has been described in literature. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Specifications

Specifications

Laminin alpha-4
Monoclonal
1 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Q16363, P97927
LAMA4
Mouse
IgG2b
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
16775, 309816, 3910
Immunohistochemistry, Western Blot
CL3183
Unconjugated
LAMA4
Liquid
LAMA4
Recombit protein corresponding to Human Laminin alpha-4
Protein A
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit

Research Use Only