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Lass4 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550695

Catalog No. PA550695


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Description

Description

The antibody detects endogenous levels of total Lass4 protein.

The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6) and they are all involved in sphingolipid synthesis. LASS4 is a 394 amino acid endoplasmic reticulum, multi-pass membrane protein. LASS4 increases the levels of long ceramides such as C22:0- and C24:0-ceramides. In cells deficient for CLN9, as observed in neuronal ceroid lipofuscinosis (NCL) or Batten disease, LASS4 can increase ceramide levels and partially correct growth and apoptosis.
Specifications

Specifications

Lass4
Polyclonal
Unconjugated
CERS4
Liquid
CERS4
Synthetic peptide corresponding to a region derived from internal residues of human ceramide synthase 4
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
2.3 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q9HA82
LASS4
Rabbit
IgG
100 μL
-20°C
Primary
79603
Documents
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