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LC3B Recombinant Rabbit Monoclonal Antibody (2H30L32), Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Supplier:  Thermo Scientific 700712

Catalog No. PI700712

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This antibody is predicted to react with mouse based on sequence homology. Intact IgG appears on a non-reducing gel as ∽150 kDa band and upon reduction generating a ∽25 kDa light chain band and a ∽50 kDa heavy chain. Recombit rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombit rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

LC3B (Autophagy Marker Light Chain 3B, MAP1A/MAP1B LC3 B) in humans, is encoded by the gene MAP1LC3B (Microtubule-associated proteins 1A/1B light chain 3B). LC3B is associated with microtubule assembly and important is in neurogenesis. Recent studies indicate that LC3B plays a vital role in autophagy, a process that involves the bulk degradation of cytoplasmic component. Three human LC3 isoforms undergo post-translational modifications during autophagy. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). LC3B is a microtubule-associated protein that mediate the physical interactions between microtubules and components of the cytoskeleton. LC3B may play a role in processes involving cancer, aging, metabolic and neurodegenerative disorders and cardiovascular/pulmonary diseases.


Recombinant Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide
Q9GZQ8, Q9CQV6, Q62625
Recombit human LC3B protein corresponding to amino acids 2–120
100 μg
Human, Mouse, Rat
ChIP assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
LC3, LC3B, LC3 beta, MAP1LC3A, MAP1LC3B, MAP1LC3, Microtubule-associated proteins 1A/1B light chain, MAP1A/MAP1B LC3, MAP1 light chain 3-like protein 2, MAP1 light chain 3-like protein 1, Microtubule-associated proteins 1A/1B light chain 3B
Protein A
64862, 67443, 81631
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.


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