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LEPR Rabbit anti-Human, Mouse, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 209661AP

Catalog No. 50-173-3179


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Description

Description

This antibody can recognize long (LEPRb) and short (LEPRa,c,d) isoforms. This antibody detects endogenous LEPR with an apparent molecular weight of 150 kDa, which is larger than the predicted molecular weight, probably due to glycosylation.

The leptin (OB-R) receptor is a member of the cytokine receptor superfamily which plays an important role in mammalian body weight homeostasis and energy balance. Ligand-induced activation of the OB-R by the adipose tissue-secreted hormone, leptin, appears to activate downstream signaling events through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. Leptin can homo-dimerize OB-R extracellular domains while downstream signaling events are initiated upon homo-dimerization of OB-R intracellular domains. Several isoforms of the OB-R which differ in length and signaling capabilities have been reported. RNA transcripts encoding the OB-R long form have been found in the choroid plexus and in the hypothalamus which has been proposed as a control center for satiety and energy expenditure. Mutations in either the mouse OB-R (db) or leptin (ob) genes have been shown to result in early-onset obesity. Metabolic abnormalities attributable to these genotypes include hypercorticoidemia, hyperinsulinemia and insulin resistance, hyperglycemia, altered CNS activity, reduced metabolic rate of brown adipose tissue, and a large increase in white adipose tissue.
Specifications

Specifications

LEPR
0.34 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P48356, P48357
CD295, DB, HuB219, LEP R, LEPR, leptin receptor, OB R, OB receptor, OBR
Rabbit
IgG
150 μL
-20°C
Primary
16847, 3953
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
Unconjugated
LEPR
Liquid
LEPR
Peptide
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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