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Leptin Rabbit anti-Human, Polyclonal, Bioss Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  BiossSupplier Diversity Partner BS4604R

Catalog No. 50-198-6103


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Description

Description

Leptin is a 167 amino acid long protein hormone with important effects in regulating body weight, metabolism and reproductive function. Leptin is approximately 16 kDa in mass and encoded by the obese (ob) gene. Leptin is expressed predominantly by adipocytes, which fits with the idea that body weight is sensed as the total mass of fat in the body. Smaller amounts of leptin are also secreted by cells in the epithelium of the stomach and in the placenta. Leptin receptors are highly expressed in areas of the hypothalamus known to be important in regulating body weight, as well as in T lymphocytes and vascular endothelial cells. Leptin ft.s effects on body weight are mediated through effects on hypothalamic centers that control feeding behavior and hunger, body temperature and energy expenditure. Leptin is involved in regulating food intake, energy expenditure, and adiposity through hypothalamic leptin receptors. Leptin promotes hematopoiesis, angiogenesis, wound healing, inflammation, immune responses, influences pubertal development and fetal growth. Studies have investigated the role of leptin in obesity, anorexia nervosa, insulin resistance, and hypertension. Leptin also has thermogenic actions and regulates enzymes of fatty acid oxidation. Severe hereditary obesity in rodents and humans can be caused by defects in leptin production.
Specifications

Specifications

Leptin
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
Lep
Liquid
Rabbit
IgG
100 μL
-20°C
Primary
3952
Lep
1 μg/mL
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
P41159
CD295 antigen; H-Leptin; HuB219; Lep; LEPD; LEP-R; Leptin; leptin (murine obesity homolog); leptin (obesity homolog, mouse); leptin precursor; Ob; obese; Obese protein; obese, mouse, homolog of; Obesity factor; obesity protein; OB-R; OBS
KLH conjugated synthetic peptide derived from human Leptin.
Protein A
RUO
Antibody
Polyclonal
Human
SDS
Documents
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