LGI1 Mouse anti-Human, Mouse, Rat, Clone: S283-7, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527652
DescriptionThe leucine-rich, glioma inactivated gene 1 (LGI1) was first identified as a candidate tumor suppressor gene for glioma and may play a role in other cancers. LGI1 is a member of a family of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 serves as a ligand to ADAM22, a metalloprotease localized at the synapse. Mutations in LGI1 account for nearly half of autodomit lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predomit auditory symptoms. Two isoforms of LGI1 are known to exist.
|PBS with 50% glycerol and 0.1% sodium azide; pH 7.4|
|O95970, Q8K4Y5, Q9JIA1|
|ADLTE, ADPAEF, ADPEAF, Epitempin 1, EPT, ETL1, IB1099, leucine rich glioma inactivated 1, OTTHUMP00000020121, OTTHUMP00000020122|
|252892, 56839, 9211|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot|
|Fusion protein amino acids 37-113 (LRRNT domain and first LRR repeat) of mouse LGI1. Rat: 100% identity (77/77 amino acids identical). Human: 98% identity (76/77 amino acids identical). ∽50% identity with LGI2, LGI3 and LGI4.|
|Human, Mouse, Rat|
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