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LGR5 Mouse anti-Human, Clone: OTI2H7, liquid, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner TA502948

Catalog No. 50-167-3943


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Description

Description

G protein-coupled receptor GPR49 has been reported to be expressed in brain, skeletal muscle, placenta, and spinal cord. ESTs have been isolated from normal human brain (amygdala), embryo, and placenta libraries and from human germ cell, uterus, and brain libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This ""turn-off"" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
Specifications

Specifications

LGR5
Monoclonal
0.72 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
O75473
FEX, GPR49, GPR67, GRP49, HG38
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
8549
Immunohistochemistry (Paraffin), Western Blot
OTI2H7
Unconjugated
LGR5
Liquid
LGR5
Human recombit protein fragment corresponding to amino acids 250-550 of human LGR5 produced in 293T Cell.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
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