LIFR Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA588754

Catalog No. PIPA588754

Description

Immunogen sequence: NPYTLYTFRI RCSTETFWKW SKWSNKKQHL TTEASPSKGP DTWREWSSDG KNLIIYWKPL PINEANGKIL SYNVSCSSDE ETQSLSEIPD PQHKAEIRLD KNDYIISVVA KNSVGSSPPS KIASMEIPND DLKIEQVVGM GKGILLTWHY DPNMTCDYVI KWCNSSRSEP CLMDWRKVPS NSTETVIESD EFRPGIRYNF F; Positive Samples: Mouse skeletal muscle; Cellular Location: Cell membrane, Single-pass type I membrane protein

This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene.

Specifications

• Antigen: LIFR
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Lifr
• Gene Symbols: Lifr
• Immunogen: Recombit fusion protein containing a sequence corresponding to amino acids 500-700 of human LIFR
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Concentration: 3.32 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P42703
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16880
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid