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LIM1 Mouse anti-Human, Clone: OTI2D5, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525920

Catalog No. PIMA525920


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Description

Description

During development, genetically distinct subtypes of motor neurons express unique combinations of LIM-type homeodomain factors, which regulate cell migration and guide motor axons to establish the fidelity of a binary choice in axonal trajectory. The LIM gene family encodes a set of gene products, which carry the LIM domain, a unique cysteine-rich zinc-binding domain. At least 40 members of this family have been identified in vertebrates and invertebrates, and are distributed into 4 groups according to the number of LIM domains and to the presence of homeodomains and kinase domains. The overlapping expression of LHX1, LHX3, LHX4, Isl-1 and Isl-2 in developing motorneurons along the spinal column may influence the establishment of specific motorneuron subtypes. The human LHX1 gene maps to chromosome 11p13-p12 and encodes a 384 amino acid protein. The human LHX1 transcript is assembled from five exons, which are separated by introns ranging in size from 93 nt to 2.3 kb. The two LIM domains are entirely contained in the first and second exons, respectively, while the homeodomain is split into exons three and four.
Specifications

Specifications

LIM1
Monoclonal
0.75 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P48742
LIM/homeobox protein Lhx1; LIM homeobox protein 1; Homeobox protein Lim-1; hLim-1; LIM-1; LIM1; LHX-1
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
3975
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI2D5
Unconjugated
LHX1
Liquid
LHX1
Human recombit protein fragment corresponding to amino acids 100-362 of LHX1 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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