LIN28B Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA549685
The antibody detects endogenous levels of total LIN28B protein.Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5 ft.-GGAG-3 ft. motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5 ft.-GGAG-3 ft. motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.
|Peptide sequence around aa.242∽246( P-S-V-Q-K) derived from Human LIN28B|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.4|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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