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Livin Mouse anti-Human, Clone: OTI1D12, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525012

Catalog No. PIMA525012


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Description

Description

Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel member in the IAP protein family was recently identified and designated Livin and KIAP for kidney IAP. Livin/XIAP contains a single baculoviral IAP repeat (BIR) domain and a RING finger domain and has two isoforms termed Livin-alpha and Livin-beta. Transfection of Livin in cells resulted in protection from apoptosis induced by FADD, BAX, RIP, RIP3 and DR6. Livin has direct interaction with several caspases including caspase-3, -7, and -9. Livin inhibits the activation of caspase-9 induced by Apaf-1, cytochrome c, and dATP. The two isoforms of Livin appear to have different functions and tissue distributions.
Specifications

Specifications

Livin
Monoclonal
0.36 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q96CA5
Baculoviral IAP repeat-containing protein 7; Kidney inhibitor of apoptosis protein; KIAP; Livin; Melanoma inhibitor of apoptosis protein; ML-IAP; RING finger protein 50; UNQ5800/PRO19607/PRO21344; KIAP; LIVIN; MLIAP; RNF50; BIRC7
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
79444
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
OTI1D12
Unconjugated
BIRC7
Liquid
BIRC7
Full length human recombit protein of BIRC7 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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