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Tocris™ LM11A 31 dihydrochloride

Nonpeptide p75NTR ligand; neuroprotective

Manufacturer:  Tocris™ 5046/50

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Catalog No. 50-465-0R


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Disclaimers:

For Research Use Only


Specifications

Description

Nonpeptide p75NTR ligand; blocks p75-mediated cell death and also increases proliferation and survival of hippocampal neural progenitors. Exhibits no effect on nerve growth factor (NGF) binding to TrkA. Prevents and reverses atrophy of cholinergic neurites, as well as reversing Alzheimer's Disease (AD) pathologies in mid- to late-stage AD mice models. Shown to promote functional recovery in a mouse model of spinal cord injury. Orally available and brain penetrant.
  • Chemical Name: (2S,3S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide dihydrochloride
  • Formula: C12H25N3O2.2HCl
  • CAS Number: 1243259-19-9
  • Solubility: Soluble to 100mM in water and to 100mM in DMSO
  • Purity: >98
Description & Specifications

Specifications

LM11A 31 dihydrochloride
>98
50mg
LM11A 31 dihydrochloride
316.27
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