LNX2 Recombinant Polyclonal Antibody (22HCLC), Invitrogen™
Rabbit Recombinant Polyclonal Antibody
Supplier: Thermo Scientific 710665
This antibody is predicted to react with Goat, Bovine, Horse, Pig, Cat and Rabbit. Recombit rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombit monoclonal antibodies, providing the best of both worlds – the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombit antibody. While functionally the same as a polyclonal antibody – recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets – a recombit rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.LNX2 (Ligand of Numb Protein X 2) protein is encoded by the LNX2 gene located on chromosome 13 in humans and is known as PDZRN1 (PDZ domain-containing RING finger 1). It is through its PDZ domains that LNX2 forms oligomers and interacts with some of its target proteins. LNX2 is best studied as a E3 ubiquitin ligase that also contains the NPXY motifs which allows binding to the Numb protein. This interaction has been shown to be responsible for ubiquitination of Numb, which prevents the proteosomal degradation of Notch intracellular domain (NICD) and thus modulates the Notch signaling pathway.
|PBS with 0.09% sodium azide; pH 7.2|
|3 synthetic peptides corresponding to human LNX2 (aa 129-145, 442-458, 671-683)|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|PDZRN1, Ligand of Numb protein X 2, Numb-binding protein 2, PDZ domain-containing RING finger protein 1|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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