Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Organoheterocyclic compounds
  6. Lactones
  7. Lovastatin, 97%, Thermo Scientific Chemicals

Lovastatin, 97%, Thermo Scientific Chemicals

Catalog Number p-7035086
Click to view available options
Quantity:
5 g
25 g
75330-75-5
C24H36O5
404.55
MFCD00072164
PCZOHLXUXFIOCF-BXMDZJJMSA-N
lovastatin, mevinolin, mevacor, monacolin k, lovalip, altoprev, lovalord, mevinacor, nergadan, 6alpha-methylcompactin
53232
CHEBI:40303
(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12
75330-75-5
C24H36O5
404.55
MFCD00072164
PCZOHLXUXFIOCF-BXMDZJJMSA-N
lovastatin, mevinolin, mevacor, monacolin k, lovalip, altoprev, lovalord, mevinacor, nergadan, 6alpha-methylcompactin
53232
CHEBI:40303
(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12

Description

Lovastatin is a cholesterol lowering drug and competitive inhibitor of HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. It increases cellular resistance to anticancer agents such as doxorubicin and induces apoptosis in myeloma cells. It causes cell cycle arrest in G1 and G2/M phases.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Lovastatin is a cholesterol lowering drug and competitive inhibitor of HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. It increases cellular resistance to anticancer agents such as doxorubicin and induces apoptosis in myeloma cells. It causes cell cycle arrest in G1 and G2/M phases.

Solubility
Soluble in DMSO (10 mg/ml), ethanol (10 mg/ml), methanol, chloroform, acetone, acetonitrile, DMF, and water (0.4 µg/ml).

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents and heat.
TRUSTED_SUSTAINABILITY
Melting Point 175°C
Quantity 5 g
Solubility Information Soluble in DMSO (10mg/ml),ethanol (10mg/ml),methanol,chloroform,acetone,acetonitrile,DMF,and water (0.4 μg/ml).
Formula Weight 404.56
Percent Purity 97%
Chemical Name or Material Lovastatin

Safety and Handling

Hazard Category H317-H351-H361d
Hazard Statement GHS H Statement
H302-H315-H319-H335
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Precautionary Statement P201-P202-P261-P272-P280g-P281-P302+P352-P308+P313-P333+P313-P363-P501c
RTECSNumber EK7907000
TSCA No
Recommended Storage Ambient temperatures
SDS

RUO – Research Use Only

Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit