Invitrogen™ LOX-1 Monoclonal Antibody (23C11)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA549083

Catalog No. FERMA549083

Description

Monoclonal antibody 23C11 neutralizes LOX-1 and inhibits Hsp70 binding to dendritic cells and Hsp70-induced antigen cross-presentation. In vivo, targeting LOX-1 with a tumor antigen using anti-LOX-1 antibody 23C11 induces anti-tumor immunity.

LOX-1 (lectin-like oxidized LDL receptor -1) is a 40-50 kDa type II membrane glycoprotein class E scavenger receptor expressed by endothelial cells, macrophages, activated platelets and smooth muscle cells. LOX-1 binds to a wide range of ligands, including oxidized low-density lipoprotein (oxLDL), hypochlorite modified high-density lipoprotein (HDL), aged /apoptotic cells, activated platelets and bacteria, reflecting its versatile physiological functions.

Specifications

• Antigen: LOX-1
• Classification: Monoclonal
• Concentration: 100 μg/mL
• Formulation: PBS with 0.1% BSA and no preservative
• Gene Accession No.: P78380
• Gene Symbols: OLR1
• Immunogen: Fusion protein of extracellular domain (aa 71-273) of human LOX-1 with murine Fc-gamma1 (LOX-1-muFc) produced in PEAK cells.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Functional Assay, Immunocytochemistry
• Clone: 23C11
• Conjugate: Unconjugated
• Gene: OLR1
• Gene Alias: CLEC8A; C-type lectin domain family 8 member A; hLOX 1; hLOX1; hLOX-1; lectin-like oxidized LDL receptor; lectin-like oxidized LDL receptor 1; lectin-like oxidized low-density lipoprotein receptor; Lectin-like oxidized low-density lipoprotein receptor-1; lectin-like oxLDL receptor 1; lectin-type oxidized LDL receptor 1; LOX 1; LOX1; LOX-1; LOXIN; Oldlr1; Oldr1; OLR1; ox LDL receptor 1; oxidised low density lipoprotein (lectin-like) receptor 1; oxidized low density lipoprotein (lectin-like) receptor 1; oxidized low density lipoprotein receptor 1; oxidized low-density lipoprotein receptor 1; Oxidized low-density lipoprotein receptor 1, soluble form; ox-LDL receptor 1; Scare1; scavenger receptor class E, member 1; sLOX 1; SLOX1; soluble LOX 1; SR-EI
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 4973
• Content And Storage: 4°C
• Form: Liquid