Invitrogen™ LPIN1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA116997

Catalog No. PIPA116997

Description

Suggested positive control: 3T3-L1 cell lysates, antigen standard for LPIN1 (transient overexpression lysate).

The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2 and Lipin-3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC-1A; target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARA. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.

Specifications

• Antigen: LPIN1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LPIN1
• Gene Alias: 4631420P06; DKFZp781P1796; Fatty liver dystrophy protein; Fld; KIAA0188; lipin 1; Lipin1; lipin-1; LPIN1; mKIAA0188; PAP1; Phosphatidate phosphatase LPIN1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14245, 23175, 313977
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.8 mg/mL
• Formulation: PBS with 30% glycerol and 0.1% sodium azide
• Gene Accession No.: Q14693, Q91ZP3
• Gene Symbols: LPIN1
• Immunogen: A synthetic peptide to an internal region (within residues 300-400) of the human LPIN1 protein.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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