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LRRK2 G2019S Full Length Protein Non-distribution product as customer accommodation.

LRRK2 G2019S Full Length Protein

Manufacturer:  LIFE TECHNOLOGIES A15200

Catalog No. A15200


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Description

Description

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multidomain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease. This full-length, purified and active LRRK2 G2019S mutant protein may be useful in research to better understand the most common Parkinson's disease-relevant mutant, as well as to explore the mechanisms underlying the disease.

  • Increase disease relevance by interrogating a purified and active full-length LRRK2 protein
  • Uncover novel compounds or hits specific to the full-length form
  • Advance Parkinson's research using the full-length protein and validated assays

    Related Links:
  • LRRK2 tools for advancing Parkinson's disease research
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  • Specifications

    Specifications

    NP_940980.3
    Pharma and biopharma, protein assays and analysis, target and lead identification and validation
    LRRK2 G2019S Full Length Protein
    10μg
    For research use only. Not for use in diagnostic procedures
    AURA17, DARDARIN, PARK8, RIPK7, ROCO2
    LRRK2 G2019S Full Length was pre-diluted in enzyme dilution buffer and assayed in 20mM Tris (pH 7.5), 10mM MgCl2, 1mM EGTA, 1mM Na3VO4, 5mM β-glycerophosphate, 2mM DTT, 0.02% Triton™ X-100, 100μM ATP, 250μM ERM (LRRKtide) peptide substrate (RLGRDKYKTLRQIRQ) (PV5093) and trace [32P]-γ-ATP for 10 minutes at 30°C
    Mammalian
    LRRK2 G2019S Full Length Protein
    Human
    0.22mg/mL
    288kDa
    90% by SDS-PAGE
    –68 to –85°C
    1 Each
    LRRK2 G2019S Full Length Protein
    Kinase assay
    LRRK
    120nmoles of phosphate transferred to ERM (LRRKtide) peptide substrate (RLGRDKYKTLRQIRQ) (PV5093) per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 2.08μg/mL
    DYKDDDDK
    Documents
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    For Research Use Only. Not for use in diagnostic procedures.