LRWD1 Rabbit anti-Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA571585

Catalog No. PIPA571585

Description

Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.

Specifications

• Antigen: LRWD1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Lrwd1
• Gene Alias: CENP-33; ORCA; ORC-associated protein; centromere protein 33; leucine-rich repeat and WD repeat-containing protein 1; origin recognition complex associated; origin recognition complex-associated protein
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 71735
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.45 mg/mL
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: Q8BUI3
• Gene Symbols: Lrwd1
• Immunogen: KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human LRWD1
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG