Potent and selective positive allosteric modulator at the mGlu5 receptor (EC50 = 24nM). Has no activity at mGlu1-4, mGlu8 and GABAB receptors. Reverses methylazoxymethanol acetate (MAM)-induced deficits in reversal learning memory and normalizes SDZ 220-581 and RO 63-1908-induced alterations in instrumental responses in rat models. Promotes wakefulness in vivo. Brain penetrant and orally active.
Chemical Name: N-(1-Methylethyl)-5-[2-(4-pyridinyl)ethynyl]-2-pyridinecarboxamide
CAS Number: 1401031-52-4
Solubility: Soluble to 100mM in DMSO and to 20mM in ethanol
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