Tocris™ LSN 2463359

Potent and selective positive allosteric modulator at mGlu5

Manufacturer: Tocris™ 5275/10

 View all options for this product

Catalog No. 52-751-0

  Check Availability
Add to Cart


For Research Use Only


    Product Type LSN 2463359
    Inhibitors LSN 2463359
    Purity >99
    Molecular Weight 265.31
    Quantity 10mg

    Potent and selective positive allosteric modulator at the mGlu5 receptor (EC50 = 24nM). Has no activity at mGlu1-4, mGlu8 and GABAB receptors. Reverses methylazoxymethanol acetate (MAM)-induced deficits in reversal learning memory and normalizes SDZ 220-581 and RO 63-1908-induced alterations in instrumental responses in rat models. Promotes wakefulness in vivo. Brain penetrant and orally active.

    • Chemical Name: N-(1-Methylethyl)-5-[2-(4-pyridinyl)ethynyl]-2-pyridinecarboxamide
    • Formula: C16H15N3O
    • CAS Number: 1401031-52-4
    • Solubility: Soluble to 100mM in DMSO and to 20mM in ethanol
    • Purity: >99

  • Description & Specifications

Related Products

Product Content Feedback

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit