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LXR-alpha Polyclonal Antibody, Active Motif™
Rabbit Polyclonal Antibody
Supplier: Active Motif 61175
Description
NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.Specifications
LXR-alpha | |
Polyclonal | |
Unconjugated | |
NR1H3 | |
AU018371; liver X nuclear receptor alpha variant 1; Liver X receptor alpha; LXR; LXR alpha; LXRA; LXR-a; LXRalpha; LXRb; NER; NERI; NR1H2; Nr1h3; nuclear orphan receptor LXR-alpha; nuclear oxysterol receptor LxR-alpha; Nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 3; Oxysterols receptor LXR-alpha; RLD1; RLD-1; ubiquitously-expressed nuclear receptor 1; Unr1 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
10062, 22259 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
ChIP Assay, ChIP sequencing (ChIP-seq), Western Blot | |
Lot-Specific | |
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5 | |
Q13133, Q9Z0Y9 | |
NR1H3 | |
This LXR-alpha antibody was raised against a peptide in the N-terminal region of human LXR-alpha. | |
100 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
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