Tocris™ LY 2389575 hydrochloride

Selective negative allosteric modulator of mGlu3

Manufacturer: Tocris™ 4969/10

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Catalog No. 49-691-0

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For Research Use Only


    Product Type LY 2389575 hydrochloride
    Inhibitors LY 2389575 hydrochloride
    Purity >98
    Molecular Weight 438.58
    Quantity 10mg

    Selective negative allosteric modulator of mGlu3 (IC50 = 190nM). Exhibits > 65-fold selectivity for mGlu3 over other mGlu receptors. Abolishes the neuroprotective action of LY 379268 against amyloid β toxicity in mixed cortical neuronal and astrocyte cell cultures.

    • Chemical Name: (3S)-N-(2,4-Dichlorobenzyl)-1-(5-bromopyrimidin-2-yl)pyrrolidinyl-3-amine hydrochloride
    • Formula: C15H15BrCl2N4.HCl
    • CAS Number: 885104-09-6
    • Solubility: Soluble to 20mM in DMSO
    • Purity: >98

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