Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Organoheterocyclic compounds
  6. Azoles
  7. Pyrazoles
  8. LY 364947, Tocris Bioscience™

LY 364947, Tocris Bioscience™

Click to view available options
Quantity:
1 mg
10 mg
This item is not returnable. View return policy
396129-53-6
C17H12N4
272.311
IBCXZJCWDGCXQT-UHFFFAOYSA-N
tbetar-i inhibitor, 4-3-pyridin-2-yl-1h-pyrazol-4-yl quinoline, alk5 inhibitor i, tgf-beta ri kinase inhibitor, 4-5-pyridin-2-yl-1h-pyrazol-4-yl quinoline, transforming growth factor-beta type i receptor kinase inhibitor, 4-3-pyridin-2-yl 1h-pyrazol-4-yl quinoline, 3-pyridin-2-yl-4-4-quinonyl-1h-pyrazole
447966
4-(5-pyridin-2-yl-1H-pyrazol-4-yl)quinoline
C1=CC=C2C(=C1)C(=CC=N2)C3=C(NN=C3)C4=CC=CC=N4
This item is not returnable. View return policy
396129-53-6
C17H12N4
272.311
IBCXZJCWDGCXQT-UHFFFAOYSA-N
tbetar-i inhibitor, 4-3-pyridin-2-yl-1h-pyrazol-4-yl quinoline, alk5 inhibitor i, tgf-beta ri kinase inhibitor, 4-5-pyridin-2-yl-1h-pyrazol-4-yl quinoline, transforming growth factor-beta type i receptor kinase inhibitor, 4-3-pyridin-2-yl 1h-pyrazol-4-yl quinoline, 3-pyridin-2-yl-4-4-quinonyl-1h-pyrazole
447966
4-(5-pyridin-2-yl-1H-pyrazol-4-yl)quinoline
C1=CC=C2C(=C1)C(=CC=N2)C3=C(NN=C3)C4=CC=CC=N4

Description

Selective inhibitor of TGF-βRI

Selective inhibitor of TGF-β type-I receptor (TGF-β RI, TGFR-I, TβR-I, ALK-5) (IC50 values are 59, 400 and 1400 nM for TGR-β RI, TGF-β RII and MLK-7K respectively). Inhibits TGF-β-dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3) (IC50 values are 47 and 89 nM respectively). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay.
Quantity 10 mg
Formula Weight 272.31
Percent Purity >99%
Chemical Name or Material LY 364947

Safety and Handling

Recommended Storage : Store at Room Temperature

Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit