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Tocris Bioscience™ LY 404187 Available on GSA/VA Contract for Federal Government customers only.

Selective AMPA receptor positive allosteric modulator

$207.00 - $857.00

Specifications

Chemical Name or Material N-[2-(4′-Cyano[1,1′-biphenyl]-4-yl)propyl]-2-propanesulfonamide
Molecular Formula C19H22N2O2S
CAS 211311-95-4
Product Type Target: AMPA Receptor Modulators
Formula Weight 342.46
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
52-971-0 Available on GSA/VA Contract for Federal Government customers only. View Documents Tocris Bioscience™
5297/10
10mg Each for $207.00
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52-975-0 View Documents Tocris Bioscience™
5297/50
50mg Each for $857.00
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Description

Description

Selective AMPA receptor positive allosteric modulator (IC50 values are 0.15, 0.21, 1.66 and 5.65 μM for GluA2i, GluA4i, GluA3i and GluA1i respectively). Potentiates glutamate and AMPA-evoked currents in pre frontal cortex (PFC) pyramidal neurons in vitro. Has no effect on NMDA- or kainate-evoked currents; also has no effect on K+ or Na+ ion channels. Potentiates PFC glutamatergic synaptic transmission in vitro and in vivo. Induces neurite growth in combination with (S)-AMPA (Cat. No. 0254) in SH-SY5Y human neuroblastoma cells in vitro. Also reduces MPTP-induced toxicity in mice. Brain penetrant.

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Specifications

Specifications

N-[2-(4′-Cyano[1,1′-biphenyl]-4-yl)propyl]-2-propanesulfonamide
211311-95-4
342.46
C19H22N2O2S
Target: AMPA Receptor Modulators
Safety and Handling

Safety and Handling

Recommended Storage : Store at 4°C

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