MACC1 Mouse anti-Human, Clone: CL0856, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA524619
Immunogen sequence: FRSGRIAQSM SEANLIDMEA GKLSKSCNIT ECQDPDLLHN WPDAFTLRGN NASKVANPFW NQLSASNPF Highest antigen sequence identity to the following orthologs: Mouse - 57%, Rat - 27%.Metastasis associated in colon cancer 1 (MACC1) is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD). Expression of MACC1 was found significantly upregulated in maligt tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment. At least two isoforms of MACC1 are known to exist.
|PBS with 40% glycerol and 0.02% sodium azide; pH 7.2|
|7A5, SH3BP4L; SH3 domain-containing protein 7a5; metastasis-associated in colon cancer protein 1; putative binding protein 7a5|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Recombit protein corresponding to Human MACC1|
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