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MACC1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 219701AP

Catalog No. 50-173-3663


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Description

Description

MACC1 (Metastasis associated in colon cancer 1) is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD). Expression of MACC1 was found significantly upregulated in maligt tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment. At least two isoforms of MACC1 are known to exist.
Specifications

Specifications

MACC1
0.3 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q6ZN28
7A5, MACC1, SH3BP4L
Rabbit
IgG
150 μL
-20°C
Primary
238455, 346389
Immunohistochemistry (Paraffin)
Unconjugated
MACC1
Liquid
MACC1
MACC1 Fusion Protein Ag16884
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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