R&D Systems™ MagCellect Rat CD4+ T Cell Isolation Kit

CD4 also functions as a chemotactic receptor for IL-16 and, in human, as a coreceptor for the gp120 surface glycoprotein of HIV-1

Supplier:  R&D Systems™ MAGR302B

Catalog No. MAGR302B

Description

• CD4 is a transmembrane glycoprotein that is expressed predominantly on thymocytes and a subset of mature T lymphocytes
• It is a standard phenotype marker for the identification of T cell populations
• CD4 is expressed along with CD8 on double positive T cells during their development in the thymus
• Either CD4 or CD8 expression is then lost, giving rise to single positive (SP) CD4+ or CD8+ mature T cells
• CD4+ SP cells, also known as T helper cells, further differentiate into multiple subsets of CD4+ cells including Th1, Th2, Th9, Th17,Th22, Tfh, and Treg cells which regulate humoral and cellular immunity
• In human, CD4 is additionally expressed on macrophages, neutrophils, monocytes, NK cells, and neurons and glial cells in the brain
• CD4 binds directly to MHC class II molecules on antigen presenting cells
• This interaction contributes to the formation of the immunological synapse which is focused around the TCR-MHC class II-antigenic peptide interaction

Specifications

• Content And Storage: Store the unopened product at 2°C to 8°C. Do not use past expiration date.