MAGED2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 152521AP
DescriptionCheckpoint kinase 2 (Chk2) is a serine/threonine-protein kinase which functions as a cell cycle checkpoint regulator. ATM and ATR kinases are activated in response to ionizing and ultraviolet radition, and phosphorylate Thr68 and other sites in the amino-terminal region of Chk2 dimerisation and activation. Activated Chk2 phosphorylates and inhibits Cdc25C phosphates, preventing the entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage. Chk2 is a putative tumor suppressor protein, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, a familiar cancer usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|11B6, HCA10, JCL 1, MAGE D2, MAGE D2 antigen, MAGED, MAGED2, melanoma antigen family D, 2, Melanoma associated antigen D2|
|10916, 113947, 80884|
|Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot|
|MAGED2 Fusion Protein Ag6828|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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