MALT1 Mouse anti-Human, Alexa Fluor 594, Clone: MT1/410, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP233054AF594
DescriptionMALT1 Monoclonal antibody specifically detects MALT1 in Human samples. It is validated for ELISA.
|Human MALT1 recombinant fragment (aa701-808)|
|Protein G purified|
|Apoptosis, Cancer, Tumor Suppressors|
|Alexa Fluor™ 594|
|50 mM sodium borate with 0.05% sodium azide|
|caspase-like protein, DKFZp434L132, EC 3.4.22.-, MALT associated translocation, MALT lymphoma-associated translocation, MLT1, MLTMALT-lymphoma associated translocation, mucosa associated lymphoid tissue lymphoma translocation gene 1, mucosa-associated lymphoid tissue lymphoma translocation protein 1, paracaspase|
|Store at 4°C in the dark.|
|Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1) is found in extranodal low-grade B cell lymphomas. MALT1 encodes two Ig-like C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT1 gene, which maps to human chromosome 18q21, and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11;18)(q21;q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT1 caspase-like domain. MALT1 mRNA is found in pre-B cells, mature B cells and plasma cells.|
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