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MAML3 Mouse anti-Human, Clone: MAML3/1303, Novus Biologicals™
Mouse Monoclonal Antibody
Supplier: Novus Biologicals NBP2476460.02MG
SDSDocumentsProduct Certifications Promotions
DescriptionMAML3 Monoclonal specifically detects MAML3 in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.
|10mM PBS and 0.05% BSA with 0.05% Sodium Azide|
|Recombinant human MAML3 protein fragment|
|Flow Cytometry, Immunohistochemistry (Paraffin), SDS-Page, Immunofluorescence|
|Flow Cytometry 0.5-1ug/million cells, Immunohistochemistry-Paraffin 0.5-1.0ug/ml, SDS-Page, Immunofluorescence 0.5-1ug/ml|
|CAG/CTG 3, ERDA3, MAM-2, mam-3, mastermind-like 3 (Drosophila), mastermind-like protein 3, polyglutamine rich, trinucleotide repeat containing 3|
|Protein A or G purified|
|MAML3 (mastermind-like protein 3) is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jk; a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain of MAML3 is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, upregulation of MAML3 is thought to be involved in oncogenesis.|
|Store at 4C.|
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