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MAML3 Mouse anti-Human, Clone: MAML3/1303, Novus Biologicals™

Mouse Monoclonal Antibody

$229.00 - $459.00

Specifications

Antigen MAML3
Clone MAML3/1303
Dilution Flow Cytometry 0.5-1ug/million cells, Immunohistochemistry-Paraffin 0.5-1.0ug/ml, SDS-Page, Immunofluorescence 0.5-1ug/ml
Applications Flow Cytometry, Immunohistochemistry (Paraffin), SDS-Page, Immunofluorescence
Classification Monoclonal
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Products 3
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
NBP247646F
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Novus Biologicals
NBP2476460.02MG
0.02 mg
Each for $229.00
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NBP247646A
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Novus Biologicals
NBP2476460.1MG
0.1 mg
Each for $459.00
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NBP247646B
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Novus Biologicals
NBP2476460.2MG
0.2 mg This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000. N/A
Description

Description

MAML3 Monoclonal specifically detects MAML3 in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.
Specifications

Specifications

MAML3
Flow Cytometry 0.5-1ug/million cells, Immunohistochemistry-Paraffin 0.5-1.0ug/ml, SDS-Page, Immunofluorescence 0.5-1ug/ml
Monoclonal
Purified
RUO
Human
CAG/CTG 3, ERDA3, MAM-2, mam-3, mastermind-like 3 (Drosophila), mastermind-like protein 3, polyglutamine rich, trinucleotide repeat containing 3
MAML3
IgG1
Protein A or G purified
MAML3 (mastermind-like protein 3) is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jk; a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain of MAML3 is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, upregulation of MAML3 is thought to be involved in oncogenesis.
MAML3/1303
Flow Cytometry, Immunohistochemistry (Paraffin), SDS-Page, Immunofluorescence
Unconjugated
Mouse
Neuroscience
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
55534
Recombinant human MAML3 protein fragment
Primary
Store at 4C.
SDS
Product Certifications
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