MAN1B1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA550029
The antibody detects endogenous levels of total MAN1B1 protein.Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man9GlcNAc2 to produce Man8GlcNAc2, but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man5-6GlcNAc2. Tremblay L.O., Glycobiology 9:1073-1078(1999) [PubMed: 10521544]. Gonzalez D.S., J. Biol. Chem. 274:21375-21386(1999) [PubMed: 10409699]. Clark H.F., Genome Res. 13:2265-2270(2003) [PubMed: 12975309].
|Synthesized peptide derived from internal of human MAN1B1.|
|Antigen affinity chromatography|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.4|
|Endoplasmic reticulum mannosyl-oligosaccharide 1, 2-alpha-mannosidase, EC=220.127.116.11, ER alpha-1, 2-mannosidase|
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