Invitrogen™ MANEA Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552784

Catalog No. PIPA552784

Description

Immunogen sequence: GVLALSWYPP DVNDENGEPT DNLVPTILDK AHKYNLKVTF HIEPYSNRDD QNMYKNVKYI IDKYGNHPAF YRYKTKTGNA LPMFYVYDSY ITKPEKWANL LTTSGSRSIR NSPYDGLFIA LLVEEKHKYD ILQSGFDGIY T Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 88%.

N-glycosylation of proteins is initiated in the endoplasmic reticulum (ER) by the transfer of the preassembled oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from dolichyl pyrophosphate to acceptor sites on the target protein by an oligosaccharyltransferase complex. This core oligosaccharide is sequentially processed by several ER glycosidases and by an endomannosidase (E.C. 3.2.1.130), such as MANEA, in the Golgi. MANEA catalyzes the release of mono-, di-, and triglucosylmannose oligosaccharides by cleaving the alpha-1,2-mannosidic bond that links them to high-mannose glycans (Hamilton et al., 2005).

Specifications

• Antigen: MANEA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MANEA
• Gene Alias: 4932703L02Rik; alpha 1,2-endomannosidase; ENDO; Endo-alpha mannosidase; endomannosidase; glycoprotein endo-alpha-1,2-mannosidase; hEndo; Mandaselin; Manea; mannosidase endo-alpha; mannosidase, endo-alpha; mEndo
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 79694
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q5SRI9
• Gene Symbols: MANEA
• Immunogen: Recombinant protein corresponding to Human MANEA. Recombinant protein control fragment (Product #RP-90480).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG